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It's been like compared like twenty five minutes in the sauna. If you don't wear it, do you snore? Yeah, subtopics click on topics. So there are clinical studies, unfortunately, not a ton of them in the United States that are looking randomized controlled trials, looking at vitamin D, the effects of vitamin D on already, you know, patients with covid-19, which what would be great is like giving them to like first responders or health care workers and seeing like, how does it how does it what what role does it play in prevention? Joe Rogan's ENTIRE episode with Dr. Rhonda Patrick broken into short audio clips for . Or find out how you can speak to an attorney for advice on the right estate plan. And I'm like, Laird, I'm doing this thing. Where did Dr Rhonda Patrick go to school? I mean, I don't even know he's been fucked up for, like, a really bad. No, no, no. Go to legalzoom.com to get started on a last will, a living trust and more. They did. On occasion. I mean, it's just you could go on and on and on. I have like I've been to to Rick Rubin's house and we've done like it was like 200 and something. But so in areas where people are going to be exposed, perhaps you could give it to them and it would stop them from getting. And it's like, yes, it's very addictive. That means everything is probably fine because it's such an enormous part of your body. And I'll show you where your heart rate it's you had a mountain of data. And the reason for that, scientists think, is because basically. But what is known is that people with type of blood are are less susceptible to contracting covid-19 that's that's definitely known. So what do you not think is accurate? And can you take too much vitamin D? But the common cold, you know, that's that's very common. When this definition is used, the majority of the world is either deficient or inadequate. Because so many people fucked themselves up by trying to do things on their own and I did and now I'm scared. Yeah. The economy, again, like now, maybe like everyone could wear a mask if they're going to be inside around a bunch of people other better than keeping the economy better than keeping the economy close. I love it. So you think that what it did was affect your the microbiome of your mouth? I mean, there's been some small studies looking at you're talking about performance enhancements. There's 100 hundred people in the room. So I need to, I just can't, I can't ever let it go. Then you'd think, why? I mean stuff goes wrong. And I'm writing a I review article for peer review publication right now. So what's interesting is that most people that are sick eating, let's say that people are just eating like five, somewhere between five to nine servings of vegetables or fruits a day. And so I just go into like crazy mode and I like I like somehow like crawled from our bedroom all the way out to the living room. Like I'm the kind of person where, like, I like to make people happy. So there's been studies were like you could do a two minute cryo, whatever the average temperature, it's really cold, minus two for it is something like that. Some clinical studies with toddlers and some problems got really, really sick and a couple died. But once you get yourself down, you just relax and all of your weight, see how other guys doing it. It happened more than once. Everyone's on the routine. Salt it's so. So are you a fan of Kombucha, do you. Well when I do squats for sure, any time I do lunges and squats and heavy leg days, I'm a zombie for two days and like if I have a particularly intellectually challenging podcast I'll skip leg days because I know I'm just going to be too stupid. Right. And I used it for a long time. I'm involved a friend of mine, Dr. Eric Gordon, he he's put together. She's amazing. And so I took her we went to get the IBC and they did it was ten, ten grams that we did. It's a hormone. The other three that were asymptomatic had as they were, they were spreading sorry, shedding as much virus that could make them, you know, basically contagious and, you know, basically able to transmit the strains. So there's a few viruses that this happens with. According to NHANES data, older adults were 63 % more likely to have vitamin D deficiency and 46 % more likely to have vitamin D insufficiency than young adults while other sources have suggested a 70-year-old may produce 4 times less vitamin D than their former 20-year-old selves. And I think you can really focus and concentrate on an actual thing that you could be proactive about during this weird time. It's hard to tell because I do so much shit. Joe Rogan, all one word when you download the cash out from the App Store or the Google Play store to test. So there have been there have been quite a few studies looking at children that are asymptomatic, children that have mild symptoms and children that are symptomatic. Like, my Mother-In-Law has to go. That's what you need. Yeah, a lot. But it's also I got to think the SONA has a big impact because it feels like I'm on a drug. This this is not cold at all. Right. And I think that doing the sauna is making you more resilient against against infection like there. They were getting some kind of green light therapy or whatever, you know, so it was a placebo control because the placebo effect is definitely a real particularly with depression. I know at least three that I think his name is Dr Michael Bush. So so then 200 milligrams. So there has been cross the immunity. You were going to be totally shocked. Like, particularly if I wasn't exercising like like almost pre diabetic level fasting blood glucose, like when this is this is when my sleep was being disrupted, when like my son was like younger. But they're in there for like an hour, you know, and they're getting they raised their core body temperature. And unlike other unreliable bullshit ass investing tools that force you to buy entire shares of stock, Kashyap lets you invest in the market with as little as a dollar. How do you use anything to help you sleep in terms of like a meditation app or do you. Autoimmunity I like it. And and the reason that's important is because a lot of studies looking at oral vitamin C consumption and like, for instance, the common cold incidence, the common cold really depends. So I found that really interesting. Like I went to lot to Quest Quest Labs like a month before all this lockdown happened. The term vitamin D can be misleading because it does not function the same way as a vitamin. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc. Most, most of these said three months. And then and then putting them in a place where they can't get any vitamin D from the sun. I have been using a Trager Grill long before it was ever a sponsor of this podcast. But that's what drives me bonkers in all cases. I, I wanted to do it before I even talked about it for months. Do so I that. For this reason, Dr. Rhonda Patrick is extremely important. Randomized controlled trials showing that zinc, zinc acetate or zinc gluconate like lozenges, they can dramatically lower the duration of common cold. And you feel like it's like room temperature because you were just in this ice bath. I mean, it gets I've taken some friends there that have never experienced it before, and they're like, fucking you over, come on, bro, yoga. She is credited with finding the beneficial range of Vitamin D with regards to sleep and a bunch of other disorders related to a hormonal deficiency. I'm not saying that vitamin D is going to prevent you from getting covid-19 or it's a treatment, although I am involved in a clinical study where we're going to be testing a very small open arm study we can talk about. And then, so then the next day I would like look forward to doing it to see if I could do it easier again. PodClips. But like, the whole time. Like, it was like popping my jaw was I was eating a lot of sauteed kale and chewing a lot of xylitol gum when I was pregnant. Please do. So I have I do the Philipps you wear at like five o'clock, all the lights in our house go red. I want the vitamin D thing is so important. But so it wasn't a great experience because one, there was this guy who snored all night too, because it was snow camping. They're treating us like we're infants. Yeah. Well I would wonder and I know there's there's supposedly some sort of Harvard study that's ongoing right now measuring all sorts of markers in people that have done hot yoga and whether or not it mimics heat, shock proteins that are created in the sauna. And if the whiskey in the barrels not ready to go into the bottle, it doesn't. Sure. It's like they're concerned, I mean, about that and completely trying to, like, figure that all out. Full breath solution. Joe Rogan's ENTIRE episode with Dr. Rhonda Patrick broken into short audio clips for easy listening (they discuss vitamin D, vitamin K, vitamin C, zinc, nootropic gum, sauna protocols, COVID-19, and more) Close. And so she now she's wanting to do it like she's wanted to do it, like, you know, once a month at least. I got ten bottles of water and I just pouring bottles of water because it was just me in there. Mine's mine's right here. And like their critics, it's animals and blah, blah, blah. And he was that this guy was in the military. Like I went to Finland a few years ago. But after I graduated, I went to work at the Salt Institute for Biological Sciences and the way I was working in an aging lab. Like I was hot as fuck, right? And oftentimes these vaccine studies are used to kind of test the immune response and like how you're how robust your immune response is because you're you're given a vaccine and there's all different types of vaccines, you know, pieces of an antigen or different types of, you know, ways that you can you can expose someone to a bacteria or virus, but you have a response to it.